About Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) is a protein
from Homo sapiens identified by UniProt accession
O00469, 737 residues long.
MolForge cross-references it against 0 known binders and
202 disease associations.
Target properties
| Protein name | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 |
|---|
| UniProt accession | O00469 |
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| Gene | PLOD2 |
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| Organism | Homo sapiens |
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| Length | 737 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (202)
Diseases linked to this target (Open Targets).
- Bruck syndrome · score 0.70
- osteogenesis imperfecta · score 0.46
- body height · score 0.40
- Skeletal dysplasia · score 0.37
- blood protein measurement · score 0.36
- Talipes equinovarus · score 0.33
- Cleft palate · score 0.33
- Femoral bowing · score 0.33
- Radial bowing · score 0.33
- Ulnar bowing · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00469-F1 | alphafold | PREDICTED | 92.25 | — |
Amino-acid sequence (737 residues)
MGGCTVKPQL LLLALVLHPW NPCLGADSEK PSSIPTDKLL VITVATKESD GFHRFMQSAK YFNYTVKVLG QGEEWRGGDG INSIGGGQKV RLMKEVMEHY ADQDDLVVMF TECFDVIFAG GPEEVLKKFQ KANHKVVFAA DGILWPDKRL ADKYPVVHIG KRYLNSGGFI GYAPYVNRIV QQWNLQDNDD DQLFYTKVYI DPLKREAINI TLDHKCKIFQ TLNGAVDEVV LKFENGKARA KNTFYETLPV AINGNGPTKI LLNYFGNYVP NSWTQDNGCT LCEFDTVDLS AVDVHPNVSI GVFIEQPTPF LPRFLDILLT LDYPKEALKL FIHNKEVYHE KDIKVFFDKA KHEIKTIKIV GPEENLSQAE ARNMGMDFCR QDEKCDYYFS VDADVVLTNP RTLKILIEQN RKIIAPLVTR HGKLWSNFWG ALSPDGYYAR SEDYVDIVQG NRVGVWNVPY MANVYLIKGK TLRSEMNERN YFVRDKLDPD MALCRNAREM GVFMYISNRH EFGRLLSTAN YNTSHYNNDL WQIFENPVDW KEKYINRDYS KIFTENIVEQ PCPDVFWFPI FSEKACDELV EEMEHYGKWS GGKHHDSRIS GGYENVPTDD IHMKQVDLEN VWLHFIREFI APVTLKVFAG YYTKGFALLN FVVKYSPERQ RSLRPHHDAS TFTINIALNN VGEDFQGGGC KFLRYNCSIE SPRKGWSFMH PGRLTHLHEG LPVKNGTRYI AVSFIDP
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