Homeobox protein Meis1 (MEIS1)

About Homeobox protein Meis1

Homeobox protein Meis1 (MEIS1) is a protein from Homo sapiens identified by UniProt accession O00470, 390 residues long. MolForge cross-references it against 0 known binders and 277 disease associations.

Target properties

Protein name	Homeobox protein Meis1
UniProt accession	O00470
Gene	MEIS1
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (277)

Diseases linked to this target (Open Targets).

restless legs syndrome · score 0.54
electrocardiography · score 0.50
insomnia measurement · score 0.50
BMI-adjusted waist-hip ratio · score 0.50
insomnia · score 0.49
PR interval · score 0.49
mean platelet volume · score 0.48
platelet count · score 0.48
physical activity measurement · score 0.48
hemoglobin measurement · score 0.47

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00470-F1	alphafold	PREDICTED	65.33	—

Amino-acid sequence (390 residues)

MAQRYDDLPH YGGMDGVGIP STMYGDPHAA RSMQPVHHLN HGPPLHSHQY PHTAHTNAMA PSMGSSVNDA LKRDKDAIYG HPLFPLLALI FEKCELATCT PREPGVAGGD VCSSESFNED IAVFAKQIRA EKPLFSSNPE LDNLMIQAIQ VLRFHLLELE KVHELCDNFC HRYISCLKGK MPIDLVIDDR EGGSKSDSED ITRSANLTDQ PSWNRDHDDT ASTRSGGTPG PSSGGHTSHS GDNSSEQGDG LDNSVASPST GDDDDPDKDK KRHKKRGIFP KVATNIMRAW LFQHLTHPYP SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP DGQPMGGFVM DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards