About RNA polymerase II elongation factor ELL2
RNA polymerase II elongation factor ELL2 (ELL2) is a protein
from Homo sapiens identified by UniProt accession
O00472, 640 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | RNA polymerase II elongation factor ELL2 |
|---|
| UniProt accession | O00472 |
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| Gene | ELL2 |
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| Organism | Homo sapiens |
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| Length | 640 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (185)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.45
- multiple myeloma · score 0.45
- mean corpuscular hemoglobin concentration · score 0.43
- lymphatic system disease · score 0.39
- vein disorder · score 0.39
- mean corpuscular hemoglobin · score 0.38
- serum albumin measurement · score 0.32
- Varicose veins · score 0.32
- monoclonal gammopathy · score 0.32
- albumin:globulin ratio measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00472-F1 | alphafold | PREDICTED | 65.62 | — |
Amino-acid sequence (640 residues)
MAAGGTGGLR EEQRYGLSCG RLGQDNITVL HVKLTETAIR ALETYQSHKN LIPFRPSIQF QGLHGLVKIP KNDPLNEVHN FNFYLSNVGK DNPQGSFDCI QQTFSSSGAS QLNCLGFIQD KITVCATNDS YQMTRERMTQ AEEESRNRST KVIKPGGPYV GKRVQIRKAP QAVSDTVPER KRSTPMNPAN TIRKTHSSST ISQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS LGAILQQVAN LNSKDLSYTL KDYVFKELQR DWPGYSEIDR RSLESVLSRK LNPSQNAAGT SRSESPVCSS RDAVSSPQKR LLDSEFIDPL MNKKARISHL TNRVPPTLNG HLNPTSEKSA AGLPLPPAAA AIPTPPPLPS TYLPISHPPQ IVNSNSNSPS TPEGRGTQDL PVDSFSQNDS IYEDQQDKYT SRTSLETLPP GSVLLKCPKP MEENHSMSHK KSKKKSKKHK EKDQIKKHDI ETIEEKEEDL KREEEIAKLN NSSPNSSGGV KEDCTASMEP SAIELPDYLI KYIAIVSYEQ RQNYKDDFNA EYDEYRALHA RMETVARRFI KLDAQRKRLS PGSKEYQNVH EEVLQEYQKI KQSSPNYHEE KYRCEYLHNK LAHIKRLIGE FDQQQAESWS
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