About Sodium-dependent phosphate transport protein 4
Sodium-dependent phosphate transport protein 4 (SLC17A3) is a protein
from Homo sapiens identified by UniProt accession
O00476, 420 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Sodium-dependent phosphate transport protein 4 |
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| UniProt accession | O00476 |
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| Gene | SLC17A3 |
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| Organism | Homo sapiens |
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| Length | 420 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (124)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.35
- mean corpuscular hemoglobin · score 0.34
- urinary metabolite measurement · score 0.33
- testosterone measurement · score 0.27
- leukocyte count · score 0.27
- creatinine measurement · score 0.26
- hypertension · score 0.22
- hepcidin:ferritin ratio · score 0.21
- mean corpuscular volume · score 0.21
- mean corpuscular hemoglobin concentration · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00476-F1 | alphafold | PREDICTED | 78.86 | — |
Amino-acid sequence (420 residues)
MATKTELSPT ARESKNAQDM QVDETLIPRK VPSLCSARYG IALVLHFCNF TTIAQNVIMN ITMVAMVNST SPQSQLNDSS EVLPVDSFGG LSKAPKSLPA KSSILGGQFA IWEKWGPPQE RSRLCSIALS GMLLGCFTAI LIGGFISETL GWPFVFYIFG GVGCVCCLLW FVVIYDDPVS YPWISTSEKE YIISSLKQQV GSSKQPLPIK AMLRSLPIWS ICLGCFSHQW LVSTMVVYIP TYISSVYHVN IRDNGLLSAL PFIVAWVIGM VGGYLADFLL TKKFRLITVR KIATILGSLP SSALIVSLPY LNSGYITATA LLTLSCGLST LCQSGIYINV LDIAPRYSSF LMGASRGFSS IAPVIVPTVS GFLLSQDPEF GWRNVFFLLF AVNLLGLLFY LIFGEADVQE WAKERKLTRL
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