About Butyrophilin subfamily 3 member A3
Butyrophilin subfamily 3 member A3 (BTN3A3) is a protein
from Homo sapiens identified by UniProt accession
O00478, 584 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Butyrophilin subfamily 3 member A3 |
|---|
| UniProt accession | O00478 |
|---|
| Gene | BTN3A3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 584 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- type 1 diabetes mellitus · score 0.23
- mean corpuscular volume · score 0.20
- mean corpuscular hemoglobin · score 0.14
- cutaneous melanoma · score 0.12
- attempted suicide · score 0.11
- major depressive disorder · score 0.11
- thyroid disease · score 0.10
- diet measurement · score 0.10
- BMI-adjusted waist-hip ratio · score 0.09
- chronic obstructive pulmonary disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00478-F1 | alphafold | PREDICTED | 82.82 | — |
Amino-acid sequence (584 residues)
MKMASSLAFL LLNFHVSLFL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELRWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL HIEVKGYEDG GIHLECRSTG WYPQPQIKWS DTKGENIPAV EAPVVADGVG LYAVAASVIM RGSSGGGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA ALAGTLPISL LLLAGASYFL WRQQKEKIAL SRETEREREM KEMGYAATEQ EISLREKLQE ELKWRKIQYM ARGEKSLAYH EWKMALFKPA DVILDPDTAN AILLVSEDQR SVQRAEEPRD LPDNPERFEW RYCVLGCENF TSGRHYWEVE VGDRKEWHIG VCSKNVERKK GWVKMTPENG YWTMGLTDGN KYRALTEPRT NLKLPEPPRK VGIFLDYETG EISFYNATDG SHIYTFPHAS FSEPLYPVFR ILTLEPTALT ICPIPKEVES SPDPDLVPDH SLETPLTPGL ANESGEPQAE VTSLLLPAHP GAEVSPSATT NQNHKLQART EALY
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