High mobility group nucleosome-binding…

About High mobility group nucleosome-binding domain-containing protein 4

High mobility group nucleosome-binding domain-containing protein 4 (HMGN4) is a protein from Homo sapiens identified by UniProt accession O00479, 90 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	High mobility group nucleosome-binding domain-containing protein 4
UniProt accession	O00479
Gene	HMGN4
Organism	Homo sapiens
Length	90 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.10
apolipoprotein B measurement · score 0.09
heel bone mineral density · score 0.08
gastroesophageal reflux disease · score 0.07
age at first sexual intercourse measurement · score 0.07
unipolar depression · score 0.07
smoking status measurement · score 0.07
low density lipoprotein cholesterol measurement · score 0.05
total cholesterol measurement · score 0.04
body height · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00479-F1	alphafold	PREDICTED	65.15	—

Amino-acid sequence (90 residues)

MPKRKAKGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPR PKKASAKKGE KLPKGRKGKA DAGKDGNNPA KNRDASTLQS QKAEGTGDAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

High mobility group nucleosome-binding domain-containing protein 4 (HMGN4)