About Butyrophilin subfamily 3 member A1
Butyrophilin subfamily 3 member A1 (BTN3A1) is a protein
from Homo sapiens identified by UniProt accession
O00481, 513 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Butyrophilin subfamily 3 member A1 |
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| UniProt accession | O00481 |
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| Gene | BTN3A1 |
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| Organism | Homo sapiens |
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| Length | 513 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (126)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- type 1 diabetes mellitus · score 0.26
- inflammatory spondylopathy · score 0.26
- arthritis · score 0.26
- spondyloarthropathy · score 0.26
- rheumatic disease · score 0.26
- thyroid disease · score 0.25
- diet measurement · score 0.15
- BMI-adjusted waist-hip ratio · score 0.13
- platelet-to-lymphocyte ratio · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00481-F1 | alphafold | PREDICTED | 89.61 | — |
Amino-acid sequence (513 residues)
MKMASFLAFL LLNFRVCLLL LQLLMPHSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL HVDVKGYKDG GIHLECRSTG WYPQPQIQWS NNKGENIPTV EAPVVADGVG LYAVAASVIM RGSSGEGVSC TIRSSLLGLE KTASISIADP FFRSAQRWIA ALAGTLPVLL LLLGGAGYFL WQQQEEKKTQ FRKKKREQEL REMAWSTMKQ EQSTRVKLLE ELRWRSIQYA SRGERHSAYN EWKKALFKPA DVILDPKTAN PILLVSEDQR SVQRAKEPQD LPDNPERFNW HYCVLGCESF ISGRHYWEVE VGDRKEWHIG VCSKNVQRKG WVKMTPENGF WTMGLTDGNK YRTLTEPRTN LKLPKPPKKV GVFLDYETGD ISFYNAVDGS HIHTFLDVSF SEALYPVFRI LTLEPTALTI CPA
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