Nuclear receptor subfamily 5 group A member 2 (NR5A2)

About Nuclear receptor subfamily 5 group A member 2

Nuclear receptor subfamily 5 group A member 2 (NR5A2) is a protein from Homo sapiens identified by UniProt accession O00482, 541 residues long. MolForge cross-references it against 0 known binders and 299 disease associations.

Target properties

Protein name	Nuclear receptor subfamily 5 group A member 2
UniProt accession	O00482
Gene	NR5A2
Organism	Homo sapiens
Length	541 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (299)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
ulcerative colitis · score 0.47
vital capacity · score 0.47
hemoglobin measurement · score 0.45
hematocrit · score 0.45
body height · score 0.44
pancreatic carcinoma · score 0.44
waist-hip ratio · score 0.43
BMI-adjusted waist-hip ratio · score 0.43
monocyte count · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00482-F1	alphafold	PREDICTED	72.14	—

Amino-acid sequence (541 residues)

MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL GLARSHGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMSQVI QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE GSIFLVTGQQ VDYSIIASQA GATLNNLMSH AQELVAKLRS LQFDQREFVC LKFLVLFSLD VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTEKFGQLL LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards