Cytochrome c oxidase subunit FA4 (COXFA4)

About Cytochrome c oxidase subunit FA4

Cytochrome c oxidase subunit FA4 (COXFA4) is a protein from Homo sapiens identified by UniProt accession O00483, 81 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.

Target properties

Protein name	Cytochrome c oxidase subunit FA4
UniProt accession	O00483
Gene	COXFA4
Organism	Homo sapiens
Length	81 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (265)

Diseases linked to this target (Open Targets).

type 1 diabetes mellitus · score 0.62
type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.61
polycystic ovary syndrome · score 0.60
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55
metabolic syndrome · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00483-F1	alphafold	PREDICTED	92.18	—

Amino-acid sequence (81 residues)

MLRQIIGQAK KHPSLIPLFV FIGTGATGAT LYLLRLALFN PDVCWDRNNP EPWNKLGPND QYKFYSVNVD YSKLKKERPD F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards