Ubiquitin C-terminal hydrolase PSMD14 (PSMD14)

About Ubiquitin C-terminal hydrolase PSMD14

Ubiquitin C-terminal hydrolase PSMD14 (PSMD14) is a protein from Homo sapiens identified by UniProt accession O00487, 310 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Ubiquitin C-terminal hydrolase PSMD14
UniProt accession	O00487
Gene	PSMD14
Organism	Homo sapiens
Length	310 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
HIV infection · score 0.46
lysosomal storage disease · score 0.32
lung adenocarcinoma · score 0.31
head and neck squamous cell carcinoma · score 0.30
squamous cell lung carcinoma · score 0.28
feeling tense measurement · score 0.22
self reported educational attainment · score 0.18
mathematical ability · score 0.17
cognitive function measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00487-F1	alphafold	PREDICTED	81.42	—

Amino-acid sequence (310 residues)

MDRLLRLGGG MPGLGQGPPT DAPAVDTAEQ VYISSLALLK MLKHGRAGVP MEVMGLMLGE FVDDYTVRVI DVFAMPQSGT GVSVEAVDPV FQAKMLDMLK QTGRPEMVVG WYHSHPGFGC WLSGVDINTQ QSFEALSERA VAVVVDPIQS VKGKVVIDAF RLINANMMVL GHEPRQTTSN LGHLNKPSIQ ALIHGLNRHY YSITINYRKN ELEQKMLLNL HKKSWMEGLT LQDYSEHCKH NESVVKEMLE LAKNYNKAVE EEDKMTPEQL AIKNVGKQDP KRHLEEHVDV LMTSNIVQCL AAMLDTVVFK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards