About Myc box-dependent-interacting protein 1
Myc box-dependent-interacting protein 1 (BIN1) is a protein
from Homo sapiens identified by UniProt accession
O00499, 593 residues long.
MolForge cross-references it against 0 known binders and
246 disease associations.
Target properties
| Protein name | Myc box-dependent-interacting protein 1 |
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| UniProt accession | O00499 |
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| Gene | BIN1 |
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| Organism | Homo sapiens |
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| Length | 593 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (246)
Diseases linked to this target (Open Targets).
- myopathy, centronuclear, 2 · score 0.78
- Alzheimer disease · score 0.49
- family history of Alzheimer’s disease · score 0.43
- neutrophil count · score 0.39
- centronuclear myopathy · score 0.39
- autosomal recessive centronuclear myopathy · score 0.38
- late-onset Alzheimers disease · score 0.38
- autosomal dominant centronuclear myopathy · score 0.37
- myeloid white cell count · score 0.35
- lean body mass · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00499-F1 | alphafold | PREDICTED | 66.66 | — |
Amino-acid sequence (593 residues)
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKPVSLLEK AAPQWCQGKL QAHLVAQTNL LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQLRKGPP VPPPPKHTPS KEVKQEQILS LFEDTFVPEI SVTTPSQFEA PGPFSEQASL LDLDFDPLPP VTSPVKAPTP SGQSIPWDLW EPTESPAGSL PSGEPSAAEG TFAVSWPSQT AEPGPAQPAE ASEVAGGTQP AAGAQEPGET AASEAASSSL PAVVVETFPA TVNGTVEGGS GAGRLDLPPG FMFKVQAQHD YTATDTDELQ LKAGDVVLVI PFQNPEEQDE GWLMGVKESD WNQHKELEKC RGVFPENFTE RVP
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