About Claudin-5
Claudin-5 (CLDN5) is a protein
from Homo sapiens identified by UniProt accession
O00501, 218 residues long.
MolForge cross-references it against 0 known binders and
357 disease associations.
Target properties
| Protein name | Claudin-5 |
|---|
| UniProt accession | O00501 |
|---|
| Gene | CLDN5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 218 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (357)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.37
- epilepsy · score 0.37
- mean platelet volume · score 0.33
- total blood protein measurement · score 0.28
- breast adenocarcinoma · score 0.25
- genetic disorder · score 0.17
- serum albumin measurement · score 0.14
- Neurodevelopmental abnormality · score 0.11
- neoplasm · score 0.09
- schizophrenia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00501-F1 | alphafold | PREDICTED | 83.77 | — |
Amino-acid sequence (218 residues)
MGSAALEILG LVLCLVGWGG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG HMQCKVYDSV LALSTEVQAA RALTVSAVLL AFVALFVTLA GAQCTTCVAP GPAKARVALT GGVLYLFCGL LALVPLCWFA NIVVREFYDP SVPVSQKYEL GAALYIGWAA TALLMVGGCL LCCGAWVCTG RPDLSFPVKY SAPRRPTATG DYDKKNYV
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