About Krev interaction trapped protein 1
Krev interaction trapped protein 1 (KRIT1) is a protein
from Homo sapiens identified by UniProt accession
O00522, 736 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Krev interaction trapped protein 1 |
|---|
| UniProt accession | O00522 |
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| Gene | KRIT1 |
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| Organism | Homo sapiens |
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| Length | 736 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- cerebral cavernous malformation 1 · score 0.77
- famililal cerebral cavernous malformations · score 0.63
- cerebral cavernous malformation · score 0.60
- Cavernous Hemangioma · score 0.41
- angiokeratoma corporis diffusum with arteriovenous fistulas · score 0.19
- genetic disorder · score 0.19
- Seizure · score 0.15
- hemoglobin measurement · score 0.15
- vascular dementia · score 0.11
- hematocrit · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00522-F1 | alphafold | PREDICTED | 82.73 | — |
Amino-acid sequence (736 residues)
MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH FAAGGGHAEI VQILLNHPET DRHITDQQGR SPLNICEENK QNNWEEAAKL LKEAINKPYE KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK LLMKLNGQLM PTERNS
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