About Uroplakin-2
Uroplakin-2 (UPK2) is a protein
from Homo sapiens identified by UniProt accession
O00526, 184 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Uroplakin-2 |
|---|
| UniProt accession | O00526 |
|---|
| Gene | UPK2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 184 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (185)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.08
- Dent disease · score 0.05
- familial juvenile hyperuricemic nephropathy type 1 · score 0.05
- hyperprolinemia type 1 · score 0.05
- Ochoa syndrome · score 0.05
- nephronophthisis · score 0.05
- hypoxanthine guanine phosphoribosyltransferase partial deficiency · score 0.05
- multicystic dysplastic kidney · score 0.05
- ichthyosis-intellectual disability-dwarfism-renal impairment syndrome · score 0.05
- primary Fanconi syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00526-F1 | alphafold | PREDICTED | 76.78 | — |
Amino-acid sequence (184 residues)
MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL GSRK
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