About von Willebrand factor A domain-containing protein 5A
von Willebrand factor A domain-containing protein 5A (VWA5A) is a protein
from Homo sapiens identified by UniProt accession
O00534, 786 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | von Willebrand factor A domain-containing protein 5A |
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| UniProt accession | O00534 |
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| Gene | VWA5A |
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| Organism | Homo sapiens |
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| Length | 786 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- intelligence · score 0.15
- breast cancer · score 0.08
- Fuchs endothelial corneal dystrophy · score 0.06
- X-linked endothelial corneal dystrophy · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
- granular corneal dystrophy type I · score 0.05
- Cataract-microcornea syndrome · score 0.05
- macular corneal dystrophy · score 0.04
- Thiel-Behnke corneal dystrophy · score 0.04
- corneal endothelial dystrophy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00534-F1 | alphafold | PREDICTED | 84.56 | — |
Amino-acid sequence (786 residues)
MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL EGDSSSRDVF SCNVGNLQPG SKAAVTLKYV QELPLEADGA LRFVLPAVLN PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL SMVATIDSQH GIEKVQSNCP LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP SVVLEMGMPN MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM EEALGRVKLM QADLGGTEIL APLQNIYRGP SIPGHPLQLF VFTDGEVTDT FSVIKEVRIN RQKHRCFSFG IGEGTSTSLI KGIARASGGT SEFITGKDRM QSKALRTLKR SLQPVVEDVS LSWHLPPGLS AKMLSPEQTV IFRGQRLISY AQLTGRMPAA ETTGEVCLKY TLQGKTFEDK VTFPLQPKPD VNLTIHRLAA KSLLQTKDMG LRETPASDKK DALNLSLESG VISSFTAFIA INKELNKPVQ GPLAHRDVPR PILLGASAPL KIKCQSGFRK ALHSDRPPSA SQPRGELMCY KAKTFQMDDY SLCGLISHKD QHSPGFGENH LVQLIYHQNA NGSWDLNEDL AKILGMSLEE IMAAQPAELV DSSGWATILA VIWLHSNGKD LKCEWELLER KAVAWMRAHA GSTMPSVVKA AITFLKSSVD PAIFAF
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