About Delta-like protein 1
Delta-like protein 1 (DLL1) is a protein
from Homo sapiens identified by UniProt accession
O00548, 723 residues long.
MolForge cross-references it against 0 known binders and
262 disease associations.
Target properties
| Protein name | Delta-like protein 1 |
|---|
| UniProt accession | O00548 |
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| Gene | DLL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 723 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (262)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with non-specific brain abnormalities and with or without seizures · score 0.72
- cancer · score 0.56
- genetic disorder · score 0.51
- neurodegenerative disease · score 0.42
- alobar holoprosencephaly · score 0.40
- midline interhemispheric variant of holoprosencephaly · score 0.37
- autosomal dominant non-syndromic intellectual disability · score 0.37
- semilobar holoprosencephaly · score 0.37
- septopreoptic holoprosencephaly · score 0.37
- microform holoprosencephaly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00548-F1 | alphafold | PREDICTED | 75.00 | — |
Amino-acid sequence (723 residues)
MGSRCALALA VLSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGAG PPPCACRTFF RVCLKHYQAS VSPEPPCTYG SAVTPVLGVD SFSLPDGGGA DSAFSNPIRF PFGFTWPGTF SLIIEALHTD SPDDLATENP ERLISRLATQ RHLTVGEEWS QDLHSSGRTD LKYSYRFVCD EHYYGEGCSV FCRPRDDAFG HFTCGERGEK VCNPGWKGPY CTEPICLPGC DEQHGFCDKP GECKCRVGWQ GRYCDECIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCKN GATCTNTGQG SYTCSCRPGY TGATCELGID ECDPSPCKNG GSCTDLENSY SCTCPPGFYG KICELSAMTC ADGPCFNGGR CSDSPDGGYS CRCPVGYSGF NCEKKIDYCS SSPCSNGAKC VDLGDAYLCR CQAGFSGRHC DDNVDDCASS PCANGGTCRD GVNDFSCTCP PGYTGRNCSA PVSRCEHAPC HNGATCHERG HRYVCECARG YGGPNCQFLL PELPPGPAVV DLTEKLEGQG GPFPWVAVCA GVILVLMLLL GCAAVVVCVR LRLQKHRPPA DPCRGETETM NNLANCQREK DISVSIIGAT QIKNTNKKAD FHGDHSADKN GFKARYPAVD YNLVQDLKGD DTAVRDAHSK RDTKCQPQGS SGEEKGTPTT LRGGEASERK RPDSGCSTSK DTKYQSVYVI SEEKDECVIA TEV
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