About U3 small nucleolar ribonucleoprotein protein MPP10
U3 small nucleolar ribonucleoprotein protein MPP10 (MPHOSPH10) is a protein
from Homo sapiens identified by UniProt accession
O00566, 681 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | U3 small nucleolar ribonucleoprotein protein MPP10 |
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| UniProt accession | O00566 |
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| Gene | MPHOSPH10 |
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| Organism | Homo sapiens |
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| Length | 681 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- emotional symptom measurement · score 0.23
- methylmalonic acidemia · score 0.12
- N-acetyl-D-glucosamine kinase measurement · score 0.11
- endometrial cancer · score 0.10
- PHF-tau measurement · score 0.08
- glucuronate measurement · score 0.07
- blood protein measurement · score 0.04
- cancer · score 0.01
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00566-F1 | alphafold | PREDICTED | 68.53 | — |
Amino-acid sequence (681 residues)
MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN KILENGRIHG SPLQKLVIEN FDDEQIWQQL ELQNEPILQY FQNAVSETIN DEDISLLPES EEQEREEDGS EIEADDKEDL EDLEEEEVSD MGNDDPEMGE RAENSSKSDL RKSPVFSDED SDLDFDISKL EQQSKVQNKG QGKPREKSIV DDKFFKLSEM EAYLENIEKE EERKDDNDEE EEDIDFFEDI DSDEDEGGLF GSKKLKSGKS SRNLKYKDFF DPVESDEDIT NVHDDELDSN KEDDEIAEEE AEELSISETD EDDDLQENED NKQHKESLKR VTFALPDDAE TEDTGVLNVK KNSDEVKSSF EKRQEKMNEK IASLEKELLE KKPWQLQGEV TAQKRPENSL LEETLHFDHA VRMAPVITEE TTLQLEDIIK QRIRDQAWDD VVRKEKPKED AYEYKKRLTL DHEKSKLSLA EIYEQEYIKL NQQKTAEEEN PEHVEIQKMM DSLFLKLDAL SNFHFIPKPP VPEIKVVSNL PAITMEEVAP VSVSDAALLA PEEIKEKNKA GDIKTAAEKT ATDKKRERRK KKYQKRMKIK EKEKRRKLLE KSSVDQAGKY SKTVASEKLK QLTKTGKASF IKDEGKDKAL KSSQAFFSKL QDQVKMQIND AKKTEKKKKK RQDISVHKLK L
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