About Nucleolar protein 56
Nucleolar protein 56 (NOP56) is a protein
from Homo sapiens identified by UniProt accession
O00567, 594 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | Nucleolar protein 56 |
|---|
| UniProt accession | O00567 |
|---|
| Gene | NOP56 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 594 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 36 · score 0.61
- neurodegenerative disease · score 0.50
- endometrial cancer · score 0.26
- pancreatic adenocarcinoma · score 0.26
- lung adenocarcinoma · score 0.25
- ovarian cancer · score 0.25
- glioblastoma multiforme · score 0.25
- head and neck squamous cell carcinoma · score 0.25
- esophageal cancer · score 0.25
- gastric adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00567-F1 | alphafold | PREDICTED | 75.03 | — |
Amino-acid sequence (594 residues)
MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHSIVRLVA FCPFASSQVA LENANAVSEG VVHEDLRLLL ETHLPSKKKK VLLGVGDPKI GAAIQEELGY NCQTGGVIAE ILRGVRLHFH NLVKGLTDLS ACKAQLGLGH SYSRAKVKFN VNRVDNMIIQ SISLLDQLDK DINTFSMRVR EWYGYHFPEL VKIINDNATY CRLAQFIGNR RELNEDKLEK LEELTMDGAK AKAILDASRS SMGMDISAID LINIESFSSR VVSLSEYRQS LHTYLRSKMS QVAPSLSALI GEAVGARLIA HAGSLTNLAK YPASTVQILG AEKALFRALK TRGNTPKYGL IFHSTFIGRA AAKNKGRISR YLANKCSIAS RIDCFSEVPT SVFGEKLREQ VEERLSFYET GEIPRKNLDV MKEAMVQAEE AAAEITRKLE KQEKKRLKKE KKRLAALALA SSENSSSTPE ECEEMSEKPK KKKKQKPQEV PQENGMEDPS ISFSKPKKKK SFSKEELMSS DLEETAGSTS IPKRKKSTPK EETVNDPEEA GHRSGSKKKR KFSKEEPVSS GPEEAVGKSS SKKKKKFHKA SQED
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