About ATP-dependent RNA helicase DDX3X
ATP-dependent RNA helicase DDX3X (DDX3X) is a protein
from Homo sapiens identified by UniProt accession
O00571, 662 residues long.
MolForge cross-references it against 0 known binders and
392 disease associations.
Target properties
| Protein name | ATP-dependent RNA helicase DDX3X |
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| UniProt accession | O00571 |
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| Gene | DDX3X |
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| Organism | Homo sapiens |
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| Length | 662 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (392)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.81
- Intellectual disability · score 0.67
- medulloblastoma · score 0.65
- genetic disorder · score 0.55
- X-linked intellectual disability-hypotonia-movement disorder syndrome · score 0.50
- Burkitts lymphoma · score 0.49
- melanoma · score 0.49
- Neurodevelopmental disorder · score 0.47
- neurodegenerative disease · score 0.46
- Global developmental delay · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00571-F1 | alphafold | PREDICTED | 72.20 | — |
Amino-acid sequence (662 residues)
MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW SSSKDKDAYS SFGSRSDSRG KSSFFSDRGS GSRGRFDDRG RSDYDGIGSR GDRSGFGKFE RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS QIYSDGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV YGGADIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV WVEESDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAYEHHY KGSSRGRSKS SRFSGGFGAR DYRQSSGASS SSFSSSRASS SRSGGGGHGS SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW GN
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