About C-X-C chemokine receptor type 6
C-X-C chemokine receptor type 6 (CXCR6) is a protein
from Homo sapiens identified by UniProt accession
O00574, 342 residues long.
MolForge cross-references it against 0 known binders and
327 disease associations.
Target properties
| Protein name | C-X-C chemokine receptor type 6 |
|---|
| UniProt accession | O00574 |
|---|
| Gene | CXCR6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 342 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (327)
Diseases linked to this target (Open Targets).
- medulloblastoma · score 0.16
- COVID-19 · score 0.14
- neoplasm · score 0.12
- prostate adenocarcinoma · score 0.10
- pneumonia · score 0.09
- familial rhabdoid tumor · score 0.09
- cancer · score 0.09
- schwannomatosis · score 0.09
- melanoma · score 0.08
- monocyte count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00574-F1 | alphafold | PREDICTED | 82.12 | — |
Amino-acid sequence (342 residues)
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
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