About Ribonuclease T2
Ribonuclease T2 (RNASET2) is a protein
from Homo sapiens identified by UniProt accession
O00584, 256 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Ribonuclease T2 |
|---|
| UniProt accession | O00584 |
|---|
| Gene | RNASET2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 256 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (129)
Diseases linked to this target (Open Targets).
- cystic leukoencephalopathy without megalencephaly · score 0.78
- genetic disorder · score 0.41
- hypothyroidism · score 0.39
- basal cell carcinoma · score 0.39
- Thyroid preparation use measurement · score 0.38
- Crohn's disease · score 0.37
- Vitiligo · score 0.36
- autoimmune disease · score 0.35
- thyroid disease · score 0.34
- spontaneous preterm birth · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00584-F1 | alphafold | PREDICTED | 86.41 | — |
Amino-acid sequence (256 residues)
MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK IQNDCRDPPD YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV IHSFPNRSRF WKHEWEKHGT CAAQVDALNS QKKYFGRSLE LYRELDLNSV LLKLGIKPSI NYYQVADFKD ALARVYGVIP KIQCLPPSQD EEVQTIGQIE LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV CEDGPVFYPP PKKTKH
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