C-C motif chemokine 21 (CCL21)

About C-C motif chemokine 21

C-C motif chemokine 21 (CCL21) is a protein from Homo sapiens identified by UniProt accession O00585, 134 residues long. MolForge cross-references it against 0 known binders and 538 disease associations.

Target properties

Protein name	C-C motif chemokine 21
UniProt accession	O00585
Gene	CCL21
Organism	Homo sapiens
Length	134 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (538)

Diseases linked to this target (Open Targets).

rheumatoid arthritis · score 0.23
lymphocyte count · score 0.21
ulcerative colitis · score 0.14
autoimmune disease · score 0.13
ankylosing spondylitis · score 0.13
sclerosing cholangitis · score 0.13
psoriasis · score 0.13
Crohn's disease · score 0.13
neoplasm · score 0.12
hepatocellular carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00585-F1	alphafold	PREDICTED	72.67	—

Amino-acid sequence (134 residues)

MAQSLALSLL ILVLAFGIPR TQGSDGGAQD CCLKYSQRKI PAKVVRSYRK QEPSLGCSIP AILFLPRKRS QAELCADPKE LWVQQLMQHL DKTPSPQKPA QGCRKDRGAS KTGKKGKGSK GCKRTERSQT PKGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards