Atypical chemokine receptor 2 (ACKR2)

About Atypical chemokine receptor 2

Atypical chemokine receptor 2 (ACKR2) is a protein from Homo sapiens identified by UniProt accession O00590, 384 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Atypical chemokine receptor 2
UniProt accession	O00590
Gene	ACKR2
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (170)

Diseases linked to this target (Open Targets).

monocyte count · score 0.35
eosinophil count · score 0.31
neutrophil count · score 0.29
lymphocyte percentage of leukocytes · score 0.29
leukocyte count · score 0.27
CCL11 measurement · score 0.27
monocyte percentage of leukocytes · score 0.25
myeloid white cell count · score 0.24
protein measurement · score 0.23
fetal genotype effect measurement · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00590-F1	alphafold	PREDICTED	80.37	—

Amino-acid sequence (384 residues)

MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT GMNDLGERQS ENYPNKEDVG NKSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards