Gamma-aminobutyric acid receptor subunit pi (GABRP)

About Gamma-aminobutyric acid receptor subunit pi

Gamma-aminobutyric acid receptor subunit pi (GABRP) is a protein from Homo sapiens identified by UniProt accession O00591, 440 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.

Target properties

Protein name	Gamma-aminobutyric acid receptor subunit pi
UniProt accession	O00591
Gene	GABRP
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (263)

Diseases linked to this target (Open Targets).

obesity · score 0.61
epilepsy · score 0.60
pain · score 0.60
alcohol dependence · score 0.60
migraine disorder · score 0.60
delirium · score 0.59
coronary artery disease · score 0.58
Seizure · score 0.58
Agitation · score 0.57
neoplasm · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00591-F1	alphafold	PREDICTED	79.15	—

Amino-acid sequence (440 residues)

MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK FLRPNFGGEP VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE GNKSFTLDAR LVEFLWVPDT YIVESKKSFL HEVTVGNRLI RLFSNGTVLY ALRITTTVAC NMDLSKYPMD TQTCKLQLES WGYDGNDVEF TWLRGNDSVR GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR NVLYFILETY VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS ITNIINSSIS SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG RIVDYFTIQN PSNVDHYSKL LFPLIFMLAN VFYWAYYMYF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards