Podocalyxin (PODXL)

About Podocalyxin

Podocalyxin (PODXL) is a protein from Homo sapiens identified by UniProt accession O00592, 558 residues long. MolForge cross-references it against 0 known binders and 312 disease associations.

Target properties

Protein name	Podocalyxin
UniProt accession	O00592
Gene	PODXL
Organism	Homo sapiens
Length	558 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (312)

Diseases linked to this target (Open Targets).

familial nephrotic syndrome · score 0.46
systolic blood pressure · score 0.45
diastolic blood pressure · score 0.40
pulse pressure measurement · score 0.38
young-onset Parkinson disease · score 0.37
atypical juvenile parkinsonism · score 0.37
urate measurement · score 0.31
bone density · score 0.31
hemoglobin measurement · score 0.31
blood pressure · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00592-F1	alphafold	PREDICTED	52.91	—

Amino-acid sequence (558 residues)

MRCALALSAL LLLLSTPPLL PSSPSPSPSP SQNATQTTTD SSNKTAPTPA SSVTIMATDT AQQSTVPTSK ANEILASVKA TTLGVSSDSP GTTTLAQQVS GPVNTTVARG GGSGNPTTTI ESPKSTKSAD TTTVATSTAT AKPNTTSSQN GAEDTTNSGG KSSHSVTTDL TSTKAEHLTT PHPTSPLSPR QPTSTHPVAT PTSSGHDHLM KISSSSSTVA IPGYTFTSPG MTTTLLETVF HHVSQAGLEL LTSGDLPTLA SQSAGITASS VISQRTQQTS SQMPASSTAP SSQETVQPTS PATALRTPTL PETMSSSPTA ASTTHRYPKT PSPTVAHESN WAKCEDLETQ TQSEKQLVLN LTGNTLCAGG ASDEKLISLI CRAVKATFNP AQDKCGIRLA SVPGSQTVVV KEITIHTKLP AKDVYERLKD KWDELKEAGV SDMKLGDQGP PEEAEDRFSM PLIITIVCMA SFLLLVAALY GCCHQRLSQR KDQQRLTEEL QTVENGYHDN PTLEVMETSS EMQEKKVVSL NGELGDSWIV PLDNLTKDDL DEEEDTHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards