CCN family member 1 (CCN1)

About CCN family member 1

CCN family member 1 (CCN1) is a protein from Homo sapiens identified by UniProt accession O00622, 381 residues long. MolForge cross-references it against 0 known binders and 449 disease associations.

Target properties

Protein name	CCN family member 1
UniProt accession	O00622
Gene	CCN1
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (449)

Diseases linked to this target (Open Targets).

appendicular lean mass · score 0.59
body fat percentage · score 0.49
pulse pressure measurement · score 0.31
creatinine measurement · score 0.30
grip strength measurement · score 0.21
body weights and measures · score 0.18
neoplasm · score 0.12
fat body mass · score 0.12
body height · score 0.11
Rheumatoid arthritis · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00622-F1	alphafold	PREDICTED	73.13	—

Amino-acid sequence (381 residues)

MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards