Peroxisome assembly protein 12 (PEX12)

About Peroxisome assembly protein 12

Peroxisome assembly protein 12 (PEX12) is a protein from Homo sapiens identified by UniProt accession O00623, 359 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Peroxisome assembly protein 12
UniProt accession	O00623
Gene	PEX12
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder type 3B · score 0.80
peroxisome biogenesis disorder 3A (Zellweger) · score 0.79
Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.67
peroxisome biogenesis disorder · score 0.67
Zellweger syndrome · score 0.62
neurodegenerative disease · score 0.43
genetic disorder · score 0.41
peroxisome biogenesis disorder, complementation group 7 · score 0.37
reticulocyte count · score 0.31
reticulocyte measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00623-F1	alphafold	PREDICTED	81.04	—

Amino-acid sequence (359 residues)

MAEHGAHFTA ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPT HYGFLWRWFD EIFTLLDLLL QQHYLSRTSA SFSENFYGLK RIVMGDTHKS QRLASAGLPK QQLWKSIMFL VLLPYLKVKL EKLVSSLREE DEYSIHPPSS RWKRFYRAFL AAYPFVNMAW EGWFLVQQLR YILGKAQHHS PLLRLAGVQL GRLTVQDIQA LEHKPAKASM MQQPARSVSE KINSALKKAV GGVALSLSTG LSVGVFFLQF LDWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM KTVCPLCRKT RVNDTVLATS GYVFCYRCVF HYVRSHQACP ITGYPTEVQH LIKLYSPEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards