About Pirin
Pirin (PIR) is a protein
from Homo sapiens identified by UniProt accession
O00625, 290 residues long.
MolForge cross-references it against 0 known binders and
154 disease associations.
Target properties
| Protein name | Pirin |
|---|
| UniProt accession | O00625 |
|---|
| Gene | PIR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 290 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (154)
Diseases linked to this target (Open Targets).
- response to statin · score 0.21
- melanoma · score 0.08
- lung adenocarcinoma · score 0.08
- infect · score 0.08
- infection · score 0.08
- glioblastoma multiforme · score 0.08
- laryngeal squamous cell carcinoma · score 0.07
- neoplasm · score 0.07
- oral squamous cell carcinoma · score 0.07
- triple-negative breast cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00625-F1 | alphafold | PREDICTED | 96.95 | — |
Amino-acid sequence (290 residues)
MGSSKKVTLS VLSREQSEGV GARVRRSIGR PELKNLDPFL LFDEFKGGRP GGFPDHPHRG FETVSYLLEG GSMAHEDFCG HTGKMNPGDL QWMTAGRGIL HAEMPCSEEP AHGLQLWVNL RSSEKMVEPQ YQELKSEEIP KPSKDGVTVA VISGEALGIK SKVYTRTPTL YLDFKLDPGA KHSQPIPKGW TSFIYTISGD VYIGPDDAQQ KIEPHHTAVL GEGDSVQVEN KDPKRSHFVL IAGEPLREPV IQHGPFVMNT NEEISQAILD FRNAKNGFER AKTWKSKIGN
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