Importin subunit alpha-3 (KPNA4)

About Importin subunit alpha-3

Importin subunit alpha-3 (KPNA4) is a protein from Homo sapiens identified by UniProt accession O00629, 521 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Importin subunit alpha-3
UniProt accession	O00629
Gene	KPNA4
Organism	Homo sapiens
Length	521 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
influenza · score 0.46
clear cell renal carcinoma · score 0.25
systolic blood pressure · score 0.16
total cholesterol measurement · score 0.15
myeloproliferative disorder · score 0.11
pulse pressure measurement · score 0.10
azoospermia · score 0.10
eosinophil count · score 0.09
type 2 diabetes mellitus · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00629-F1	alphafold	PREDICTED	86.06	—

Amino-acid sequence (521 residues)

MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards