Netrin-3 (NTN3)

About Netrin-3

Netrin-3 (NTN3) is a protein from Homo sapiens identified by UniProt accession O00634, 580 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Netrin-3
UniProt accession	O00634
Gene	NTN3
Organism	Homo sapiens
Length	580 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

hip circumference · score 0.09
mean reticulocyte volume · score 0.03
trigeminal neuralgia · score 0.03
sitting height measurement · score 0.02
cancer · score 0.01
nonpapillary renal cell carcinoma · score 0.01
neoplasm · score 0.01
Autosomal dominant polycystic kidney disease · score 0.01
small cell lung carcinoma · score 0.01
prostate adenocarcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00634-F1	alphafold	PREDICTED	87.19	—

Amino-acid sequence (580 residues)

MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG REVLASSTCG RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR APLNVTLTVP LGKAFELVFV SLRFCSAPPA SVALLKSQDH GRSWAPLGFF SSHCDLDYGR LPAPANGPAG PGPEALCFPA PLAQPDGSGL LAFSMQDSSP PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV PYSYAATDLQ VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC HYCREGFYRD PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT GLTCNRCAPG FQQSRSPVAP CVKTPIPGPT EDSSPVQPQD CDSHCKPARG SYRISLKKFC KKDYAVQVAV GARGEARGAW TRFPVAVLAV FRSGEERARR GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG GRGPGLIAAR GSLVLPWRDA WTRRLRRLQR RERRGRCSAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards