E3 ubiquitin-protein ligase TRIM38 (TRIM38)

About E3 ubiquitin-protein ligase TRIM38

E3 ubiquitin-protein ligase TRIM38 (TRIM38) is a protein from Homo sapiens identified by UniProt accession O00635, 465 residues long. MolForge cross-references it against 0 known binders and 168 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM38
UniProt accession	O00635
Gene	TRIM38
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (168)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.34
mean corpuscular hemoglobin · score 0.31
HbA1c measurement · score 0.27
urate measurement · score 0.26
diastolic blood pressure · score 0.18
pulse pressure measurement · score 0.17
type 1 diabetes mellitus · score 0.16
testosterone measurement · score 0.16
systemic lupus erythematosus · score 0.15
cognitive function measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00635-F1	alphafold	PREDICTED	87.30	—

Amino-acid sequence (465 residues)

MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK QLRQETFCCP QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF HLFCEDEGQL ICWRCERAPQ HKGHTTALVE DVCQGYKEKL QKAVTKLKQL EDRCTEQKLS TAMRITKWKE KVQIQRQKIR SDFKNLQCFL HEEEKSYLWR LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS AQKLLQNVND TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE VDVGEGTGWD LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP TSLHLHEQPL LVGIFLDYEA GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF QVYQYSPLFL PPPGD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards