Nuclear factor 1 B-type (NFIB)

About Nuclear factor 1 B-type

Nuclear factor 1 B-type (NFIB) is a protein from Homo sapiens identified by UniProt accession O00712, 420 residues long. MolForge cross-references it against 0 known binders and 383 disease associations.

Target properties

Protein name	Nuclear factor 1 B-type
UniProt accession	O00712
Gene	NFIB
Organism	Homo sapiens
Length	420 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (383)

Diseases linked to this target (Open Targets).

macrocephaly-developmental delay syndrome · score 0.70
Intellectual disability · score 0.58
Macrocephaly · score 0.57
self reported educational attainment · score 0.51
serum gamma-glutamyl transferase measurement · score 0.48
erythrocyte count · score 0.46
genetic disorder · score 0.45
mathematical ability · score 0.42
schizophrenia · score 0.42
date of diagnosis · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00712-F1	alphafold	PREDICTED	67.24	—

Amino-acid sequence (420 residues)

MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK HPCCVLSNPD QKGKIRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER LMKSPHCTNP ALCVQPHHIT VSVKELDLFL AYYVQEQDSG QSGSPSHNDP AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP IGEIPSQPYY HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPSSPAAGS RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV AHSVISTRTP PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK NYVPSYDPSS PQTSQSWYLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards