Transcription factor E2F3 (E2F3)

About Transcription factor E2F3

Transcription factor E2F3 (E2F3) is a protein from Homo sapiens identified by UniProt accession O00716, 465 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.

Target properties

Protein name	Transcription factor E2F3
UniProt accession	O00716
Gene	E2F3
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (203)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
serum alanine aminotransferase measurement · score 0.41
cystatin C measurement · score 0.35
serum albumin measurement · score 0.35
creatinine measurement · score 0.35
body mass index · score 0.34
triglyceride measurement · score 0.34
body fat percentage · score 0.34
BMI-adjusted waist-hip ratio · score 0.34
glomerular filtration rate · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00716-F1	alphafold	PREDICTED	59.46	—

Amino-acid sequence (465 residues)

MRKGIQPALE QYLVTAGGGE GAAVVAAAAA ASMDKRALLA SPGFAAAAAA AAAPGAYIQI LTTNTSTTSC SSSLQSGAVA AGPLLPSAPG AEQTAGSLLY TTPHGPSSRA GLLQQPPALG RGGSGGGGGP PAKRRLELGE SGHQYLSDGL KTPKGKGRAA LRSPDSPKTP KSPSEKTRYD TSLGLLTKKF IQLLSQSPDG VLDLNKAAEV LKVQKRRIYD ITNVLEGIHL IKKKSKNNVQ WMGCSLSEDG GMLAQCQGLS KEVTELSQEE KKLDELIQSC TLDLKLLTED SENQRLAYVT YQDIRKISGL KDQTVIVVKA PPETRLEVPD SIESLQIHLA STQGPIEVYL CPEETETHSP MKTNNQDHNG NIPKPASKDL ASTNSGHSDC SVSMGNLSPL ASPANLLQQT EDQIPSNLEG PFVNLLPPLL QEDYLLSLGE EEGISDLFDA YDLEKLPLVE DFMCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards