About Protein Wnt-10b
Protein Wnt-10b (WNT10B) is a protein
from Homo sapiens identified by UniProt accession
O00744, 389 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Protein Wnt-10b |
|---|
| UniProt accession | O00744 |
|---|
| Gene | WNT10B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 389 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (151)
Diseases linked to this target (Open Targets).
- Split hand-split foot malformation · score 0.77
- tooth agenesis · score 0.56
- genetic disorder · score 0.19
- breast adenocarcinoma · score 0.11
- neoplasm · score 0.09
- triple-negative breast cancer · score 0.08
- metabolite measurement · score 0.07
- hepatocellular carcinoma · score 0.06
- psoriasis · score 0.05
- body height · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00744-F1 | alphafold | PREDICTED | 80.08 | — |
Amino-acid sequence (389 residues)
MLEEPRPRPP PSGLAGLLFL ALCSRALSNE ILGLKLPGEP PLTANTVCLT LSGLSKRQLG LCLRNPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG GRLPHHSAIL KRGFRESAFS FSMLAAGVMH AVATACSLGK LVSCGCGWKG SGEQDRLRAK LLQLQALSRG KSFPHSLPSP GPGSSPSPGP QDTWEWGGCN HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH GTSGSCQFKT CWRAAPEFRA VGAALRERLG RAIFIDTHNR NSGAFQPRLR PRRLSGELVY FEKSPDFCER DPTMGSPGTR GRACNKTSRL LDGCGSLCCG RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK
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