Nucleoside diphosphate kinase D, mitochondrial (NME4)

About Nucleoside diphosphate kinase D, mitochondrial

Nucleoside diphosphate kinase D, mitochondrial (NME4) is a protein from Homo sapiens identified by UniProt accession O00746, 187 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Nucleoside diphosphate kinase D, mitochondrial
UniProt accession	O00746
Gene	NME4
Organism	Homo sapiens
Length	187 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (65)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
Parkinson disease · score 0.33
lysosomal storage disease · score 0.33
multiple sclerosis · score 0.33
Alzheimer disease · score 0.33
urinary metabolite measurement · score 0.18
protein measurement · score 0.16
sphingomyelin measurement · score 0.14
non-small cell lung carcinoma · score 0.07
bone density · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00746-F1	alphafold	PREDICTED	85.01	—

Amino-acid sequence (187 residues)

MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ RRLVGDVIQR FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY MSSGPVVAMV WEGYNVVRAS RAMIGHTDSA EAAPGTIRGD FSVHISRNVI HASDSVEGAQ REIQLWFQSS ELVSWADGGQ HSSIHPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards