About Protein Wnt-7a
Protein Wnt-7a (WNT7A) is a protein
from Homo sapiens identified by UniProt accession
O00755, 349 residues long.
MolForge cross-references it against 0 known binders and
455 disease associations.
Target properties
| Protein name | Protein Wnt-7a |
|---|
| UniProt accession | O00755 |
|---|
| Gene | WNT7A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 349 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (455)
Diseases linked to this target (Open Targets).
- phocomelia, Schinzel type · score 0.77
- Fuhrmann syndrome · score 0.75
- vital capacity · score 0.45
- FEV/FVC ratio · score 0.42
- hematocrit · score 0.41
- white matter microstructure measurement · score 0.41
- lean body mass · score 0.39
- appendicular lean mass · score 0.37
- Polydactyly · score 0.37
- polydactyly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O00755-F1 | alphafold | PREDICTED | 88.52 | — |
Amino-acid sequence (349 residues)
MNRKARRCLG HLFLSLGMVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK
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