Fructose-1,6-bisphosphatase isozyme 2 (FBP2)

About Fructose-1,6-bisphosphatase isozyme 2

Fructose-1,6-bisphosphatase isozyme 2 (FBP2) is a protein from Homo sapiens identified by UniProt accession O00757, 339 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Fructose-1,6-bisphosphatase isozyme 2
UniProt accession	O00757
Gene	FBP2
Organism	Homo sapiens
Length	339 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

leukodystrophy, childhood-onset, remitting · score 0.45
t-tau:beta-amyloid 1-42 ratio measurement · score 0.33
body height · score 0.20
protein measurement · score 0.14
lean body mass · score 0.12
oral squamous cell carcinoma · score 0.07
red blood cell density measurement · score 0.07
colon carcinoma · score 0.07
appendicular lean mass · score 0.06
isolated ectopia lentis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00757-F1	alphafold	PREDICTED	93.75	—

Amino-acid sequence (339 residues)

MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLAHLYGI AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN KDAIITAKEK RGKYVVCFDP LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE KDALQCGRNI VAAGYALYGS ATLVALSTGQ GVDLFMLDPA LGEFVLVEKD VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP YGARYVGSMV ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards