Ubiquitin-conjugating enzyme E2 C (UBE2C)

About Ubiquitin-conjugating enzyme E2 C

Ubiquitin-conjugating enzyme E2 C (UBE2C) is a protein from Homo sapiens identified by UniProt accession O00762, 179 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 C
UniProt accession	O00762
Gene	UBE2C
Organism	Homo sapiens
Length	179 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (229)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
body height · score 0.16
late-onset Alzheimers disease · score 0.14
non-small cell lung carcinoma · score 0.12
hepatocellular carcinoma · score 0.12
cancer · score 0.12
neoplasm · score 0.12
breast cancer · score 0.11
esophageal squamous cell carcinoma · score 0.11
lung adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00762-F1	alphafold	PREDICTED	88.56	—

Amino-acid sequence (179 residues)

MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards