Stearoyl-CoA desaturase (SCD)

About Stearoyl-CoA desaturase

Stearoyl-CoA desaturase (SCD) is a protein from Homo sapiens identified by UniProt accession O00767, 359 residues long. MolForge cross-references it against 0 known binders and 561 disease associations.

Target properties

Protein name	Stearoyl-CoA desaturase
UniProt accession	O00767
Gene	SCD
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (561)

Diseases linked to this target (Open Targets).

Parkinson disease · score 0.47
Alzheimer disease · score 0.46
multiple sclerosis · score 0.46
lysosomal storage disease · score 0.46
neurodegenerative disease · score 0.46
basophil count · score 0.33
basophil percentage of leukocytes · score 0.27
insomnia · score 0.26
total blood protein measurement · score 0.26
mean platelet volume · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O00767-F1	alphafold	PREDICTED	89.35	—

Amino-acid sequence (359 residues)

MPAHLLQDDI SSSYTTTTTI TAPPSRVLQN GGDKLETMPL YLEDDIRPDI KDDIYDPTYK DKEGPSPKVE YVWRNIILMS LLHLGALYGI TLIPTCKFYT WLWGVFYYFV SALGITAGAH RLWSHRSYKA RLPLRLFLII ANTMAFQNDV YEWARDHRAH HKFSETHADP HNSRRGFFFS HVGWLLVRKH PAVKEKGSTL DLSDLEAEKL VMFQRRYYKP GLLMMCFILP TLVPWYFWGE TFQNSVFVAT FLRYAVVLNA TWLVNSAAHL FGYRPYDKNI SPRENILVSL GAVGEGFHNY HHSFPYDYSA SEYRWHINFT TFFIDCMAAL GLAYDRKKVS KAAILARIKR TGDGNYKSG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards