About Disks large-associated protein 1
Disks large-associated protein 1 (DLGAP1) is a protein
from Homo sapiens identified by UniProt accession
O14490, 977 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Disks large-associated protein 1 |
|---|
| UniProt accession | O14490 |
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| Gene | DLGAP1 |
|---|
| Organism | Homo sapiens |
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| Length | 977 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.34
- PHF-tau measurement · score 0.30
- testosterone measurement · score 0.30
- body height · score 0.29
- ulcerative colitis · score 0.29
- mean corpuscular volume · score 0.29
- smoking status measurement · score 0.28
- Eczematoid dermatitis · score 0.28
- eyelid sagging measurement · score 0.28
- treatment-resistant hypertension · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14490-F1 | alphafold | PREDICTED | 50.41 | — |
Amino-acid sequence (977 residues)
MKGLSGSRSH HHGVTCDSAC DSLSHHSDRK PYLLSPVEHH PADHPYYTQR NSFQAECVGP FSDPLASSTF PRRHYTSQQE LKDECALVPR TLATKANRIP ANLLDQFERQ LPLSRDGYHT LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT KSHSLEGPSK GSVNGGKASP DEAQAARYGK RSKSKERRAE PKARPSTSPG WWSSDDNLDG DMCIYHAPSG VMTMGRCPDR SASQYFLEAY NTISEQAVKA SRSNNDVKCS TCANLPVSLD TPLLKKSAWS STLTVSRARE VYQKASVNMD QAMVKSESCQ QERSCQYLQV PQDEWTGYTP RGKDDEIPCR RMRSGSYIKA MGDEDSGDSD TSPKPSPKVA ARRESYLKAT QPSLTELTTL KISNEHSPKL QIRSHSYLRA VSEVSINRSL DSLDPAGLLT SPKFRSRNES YMRAMSTISQ VSEMEVNGQF ESVCESVFSE LESQAVEALD LPMPGCFRMR SHSYVRAIEK GCSQDDECVS LRSSSPPRTT TTVRTIQSST VSSCITTYKK TPPPVPPRTT TKPFISITAQ SSTESAQDAY MDGQGQRGDI ISQSGLSNST ESLDSMKALT AAIEAANAQI HGPASQHMGN NTATVTTTTT IATVTTEDRK KDHFKKNRCL SIGIQVDDAE EPDKTGENKA PSKFQSVGVQ VEEEKCFRRF TRSNSVTTAV QADLDFHDNL ENSLESIEDN SCPGPMARQF SRDASTSTVS IQGSGNHYHA CAADDDFDTD FDPSILPPPD PWIDSITEDP LEAVQRSVCH RDGHWFLKLL QAERDRMEGW CQQMEREERE NNLPEDILGK IRTAVGSAQL LMAQKFYQFR ELCEENLNPN AHPRPTSQDL AGFWDMLQLS IENISMKFDE LHQLKANNWK QMDPLDKKER RAPPPVPKKP AKGPAPLIRE RSLESSQRQE ARKRLMAAKR AASVRQNSAT ESAESIEIYI PEAQTRL
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