About SH2B adapter protein 2
SH2B adapter protein 2 (SH2B2) is a protein
from Homo sapiens identified by UniProt accession
O14492, 632 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | SH2B adapter protein 2 |
|---|
| UniProt accession | O14492 |
|---|
| Gene | SH2B2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 632 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (93)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- creatinine measurement · score 0.32
- glomerular filtration rate · score 0.29
- BMI-adjusted hip circumference · score 0.24
- breast adenocarcinoma · score 0.18
- glioblastoma multiforme · score 0.15
- sex hormone-binding globulin measurement · score 0.10
- cortical surface area measurement · score 0.10
- C-reactive protein measurement · score 0.09
- eosinophil count · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14492-F1 | alphafold | PREDICTED | 62.13 | — |
Amino-acid sequence (632 residues)
MNGAGPGPAA AAPVPVPVPV PDWRQFCELH AQAAAVDFAH KFCRFLRDNP AYDTPDAGAS FSRHFAANFL DVFGEEVRRV LVAGPTTRGA AVSAEAMEPE LADTSALKAA PYGHSRSSED VSTHAATKAR VRKGFSLRNM SLCVVDGVRD MWHRRASPEP DAAAAPRTAE PRDKWTRRLR LSRTLAAKVE LVDIQREGAL RFMVADDAAA GSGGSAQWQK CRLLLRRAVA EERFRLEFFV PPKASRPKVS IPLSAIIEVR TTMPLEMPEK DNTFVLKVEN GAEYILETID SLQKHSWVAD IQGCVDPGDS EEDTELSCTR GGCLASRVAS CSCELLTDAV DLPRPPETTA VGAVVTAPHS RGRDAVRESL IHVPLETFLQ TLESPGGSGS DSNNTGEQGA ETDPEAEPEL ELSDYPWFHG TLSRVKAAQL VLAGGPRNHG LFVIRQSETR PGEYVLTFNF QGKAKHLRLS LNGHGQCHVQ HLWFQSVLDM LRHFHTHPIP LESGGSADIT LRSYVRAQDP PPEPGPTPPA APASPACWSD SPGQHYFSSL AAAACPPASP SDAAGASSSS ASSSSAASGP APPRPVEGQL SARSRSNSAE RLLEAVAATA AEEPPEAAPG RARAVENQYS FY
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