About Claudin-4
Claudin-4 (CLDN4) is a protein
from Homo sapiens identified by UniProt accession
O14493, 209 residues long.
MolForge cross-references it against 0 known binders and
495 disease associations.
Target properties
| Protein name | Claudin-4 |
|---|
| UniProt accession | O14493 |
|---|
| Gene | CLDN4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 209 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (495)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.29
- glioblastoma multiforme · score 0.18
- serum alanine aminotransferase measurement · score 0.11
- neoplasm · score 0.11
- gastric adenocarcinoma · score 0.10
- asthma · score 0.10
- gonorrhea · score 0.10
- ovarian neoplasm · score 0.08
- chronic obstructive pulmonary disease · score 0.08
- infection · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14493-F1 | alphafold | PREDICTED | 84.58 | — |
Amino-acid sequence (209 residues)
MASMGLQVMG IALAVLGWLA VMLCCALPMW RVTAFIGSNI VTSQTIWEGL WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALVIISIIV AALGVLLSVV GGKCTNCLED ESAKAKTMIV AGVVFLLAGL MVIVPVSWTA HNIIQDFYNP LVASGQKREM GASLYVGWAA SGLLLLGGGL LCCNCPPRTD KPYSAKYSAA RSAAASNYV
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