About Phospholipid phosphatase 1
Phospholipid phosphatase 1 (PLPP1) is a protein
from Homo sapiens identified by UniProt accession
O14494, 284 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Phospholipid phosphatase 1 |
|---|
| UniProt accession | O14494 |
|---|
| Gene | PLPP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 284 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.50
- bone quantitative ultrasound measurement · score 0.35
- lymphocyte count · score 0.34
- platelet count · score 0.34
- monocyte count · score 0.31
- HbA1c measurement · score 0.30
- body height · score 0.29
- neutrophil count · score 0.23
- bone density · score 0.20
- BMI-adjusted waist-hip ratio · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14494-F1 | alphafold | PREDICTED | 87.52 | — |
Amino-acid sequence (284 residues)
MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP
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