Phospholipid phosphatase 3 (PLPP3)

About Phospholipid phosphatase 3

Phospholipid phosphatase 3 (PLPP3) is a protein from Homo sapiens identified by UniProt accession O14495, 311 residues long. MolForge cross-references it against 0 known binders and 178 disease associations.

Target properties

Protein name	Phospholipid phosphatase 3
UniProt accession	O14495
Gene	PLPP3
Organism	Homo sapiens
Length	311 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (178)

Diseases linked to this target (Open Targets).

coronary artery disease · score 0.51
reticulocyte count · score 0.49
systolic blood pressure · score 0.46
reticulocyte measurement · score 0.46
Immature Reticulocyte Fraction Measurement · score 0.44
angina pectoris · score 0.44
pulse pressure measurement · score 0.43
hypertension · score 0.43
lymphocyte percentage of leukocytes · score 0.42
heel bone mineral density · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14495-F1	alphafold	PREDICTED	84.35	—

Amino-acid sequence (311 residues)

MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD IIDRNNHHNM M

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards