Class E basic helix-loop-helix protein 40 (BHLHE40)

About Class E basic helix-loop-helix protein 40

Class E basic helix-loop-helix protein 40 (BHLHE40) is a protein from Homo sapiens identified by UniProt accession O14503, 412 residues long. MolForge cross-references it against 0 known binders and 356 disease associations.

Target properties

Protein name	Class E basic helix-loop-helix protein 40
UniProt accession	O14503
Gene	BHLHE40
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (356)

Diseases linked to this target (Open Targets).

Thyroid preparation use measurement · score 0.36
hypothyroidism · score 0.36
alkaline phosphatase measurement · score 0.36
atopic eczema · score 0.29
thyroid disease · score 0.28
diabetes mellitus · score 0.28
autoimmune thyroid disease · score 0.28
endocrine system disease · score 0.28
serum gamma-glutamyl transferase measurement · score 0.23
Red cell distribution width · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14503-F1	alphafold	PREDICTED	59.92	—

Amino-acid sequence (412 residues)

MERIPSAQPP PACLPKAPGL EHGDLPGMYP AHMYQVYKSR RGIKRSEDSK ETYKLPHRLI EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT LKHVKALTNL IDQQQQKIIA LQSGLQAGEL SGRNVETGQE MFCSGFQTCA REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS ELLQGGTSRK PSDPAPKVMD FKEKPSSPAK GSEGPGKNCV PVIQRTFAHS SGEQSGSDTD TDSGYGGESE KGDLRSEQPC FKSDHGRRFT MGERIGAIKQ ESEEPPTKKN RMQLSDDEGH FTSSDLISSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPV LYPGLNASAA ALSSFMNPDK ISAPLLMPQR LPSPLPAHPS VDSSVLLQAL KPIPPLNLET KD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards