About Nck-associated protein 5
Nck-associated protein 5 (NCKAP5) is a protein
from Homo sapiens identified by UniProt accession
O14513, 1909 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Nck-associated protein 5 |
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| UniProt accession | O14513 |
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| Gene | NCKAP5 |
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| Organism | Homo sapiens |
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| Length | 1909 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.41
- cortical surface area measurement · score 0.39
- brain measurement · score 0.39
- neuroimaging measurement · score 0.39
- cortical thickness · score 0.39
- PR interval · score 0.36
- body height · score 0.33
- brain volume measurement · score 0.31
- FEV/FVC ratio · score 0.28
- erythrocyte count · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14513-F1 | alphafold | PREDICTED | 43.11 | — |
Amino-acid sequence (1909 residues)
MEGKRQLEKR DFGKRLSLDS SLVEYMDSNK YIEHLLTQLE EQHRSLWREK LAVARLQREV AQRTSEGAMH EKLIHELEEE RHLRLQSEKR LQEVTLESER NRIQMRSLQQ QFSRMEETVR NLLQSQGSPE QKKEETVNIM VYQEKLSEEE RKHKEALEDL HMVVDEDSRS ESSSTDEGKE KTKLLLERLK ALEAENSALA LENENQREQY ERCLDEVANQ VVQALLTQKD LREECVKLKT RVFDLEQQNR TLSILFQQRV RPTSDLLLQK LHSRLLDLSS GDLLSEVERN RSLTQSRTDA EVHEHQLNTK SALKCPGLGA VIPGHLCPRN SYSSSSELSL SSTCSEYSSG SSYTWHDGKN LRKRQSSQNW DKRLSIDSSL PSGFASPTNE LPPTRIKESH ILEGLRKLQK RKVLLEPPSV ITKWGYKDCM NSNEGIYSPG IKSSSLKEYP PCKTADLGSP CKEPHKTFVY DLDSHVDADD DPSTLALLQA VPNQSCRPHG SKLTHSVSDS LFGWETNRKH FLEGTSSVYP KERPEKLTSC ASSCPLEMKL CPSVQTPQVQ RERGPQGQGH GRMALNLQLS DTDDNETFDE LHIESSDEKS PSDVSLAADT DKSVENLDVL VGFGKSLCGS PEEEEKQVPI PSETRPKTFS FIKQQRVVKR TSSEECVTVI FDAEDGEPIE FSSHQTGVVT VTRNEISINS TPAGPKAEHT ELLPQGIACL QPRAAARDYT FFKRSEEDTE KNIPKDNVDN VPRVSTESFS SRTVTQNPQQ QKLVKPTHNI SCQSNSRSSA PMGIYQKQNL TKIPPRGKSS PQKSKLMEPE ATTLLPSSGL VTLEKSPALA PGKLSRFMKT ESSGPLFELR SDPHIPKHSA QLPHSSRMPS RRDWVQCPKS QTPGSRSRPA IESSDSGEPP TRDEHCGSGP EAGVKSPSPP PPPGRSVSLL ARPSYDYSPA PSSTKSETRV PSETARTPFK SPLLKGISAP VISSNPATTE VQRKKPSVAF KKPIFTHPMP SPEAVIQTRC PAHAPSSSFT VMALGPPKVS PKRGVPKTSP RQTLGTPQRD IGLQTPRISP STHEPLEMTS SKSVSPGRKG QLNDSASTPP KPSFLGVNES PSSQVSSSSS SSSPAKSHNS PHGCQSAHEK GLKTRLPVGL KVLMKSPQLL RKSSTVPGKH EKDSLNEASK SSVAVNKSKP EDSKNPASME ITAGERNVTL PDSQAQGSLA DGLPLETALQ EPLESSIPGS DGRDGVDNRS MRRSLSSSKP HLKPALGMNG AKARSHSFST HSGDKPSTPP IEGSGKVRTQ IITNTAERGN SLTRQNSSTE SSPNKAPSAP MLESLPSVGR PSGHPSSGKG SLGSSGSFSS QHGSPSKLPL RIPPKSEGLL IPPGKEDQQA FTQGECPSAN VAVLGEPGSD RRSCPPTPTD CPEALQSPGR TQHPSTFETS STSKLETSGR HPDASATATD AVSSEAPLSP TIEEKVMLCI QENVEKGQVQ TKPTSVEAKQ KPGPSFASWF GFRKSRLPAL SSRKMDISKT KVEKKDAKVL GFGNRQLKSE RKKEKKKPEL QCETENELIK DTKSADNPDG GLQSKNNRRT PQDIYNQLKI EPRNRHSPVA CSTKDTFMTE LLNRVDKKAA PQTESGSSNA SCRNVLKGSS QGSCLIGSSI STQGNHKKNM KIKADMEVPK DSLVKEANEN LQEDEDDAVA DSVFQSHIIE SNCQMRTLDS GIGTFPLPDS GNRSTGRYLC QPDSPEDAEP LLPLQSALSA VSSMRAQTLE REVPSSTDGQ RPADSAIVHS TSDPIMTARG MRPLQSRLPK PASSGKVSSQ KQNEAEPRPQ TCSSFGYAED PMASQPLPDW GSEVAATGTQ DKAPRMCTYS ASGGSNSDSD LDYGDNGFGA GRGQLVKALK SAAPEIETT
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