Cyclin-dependent kinase 2-associated protein 1…

About Cyclin-dependent kinase 2-associated protein 1

Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is a protein from Homo sapiens identified by UniProt accession O14519, 115 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 2-associated protein 1
UniProt accession	O14519
Gene	CDK2AP1
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (130)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.24
eosinophil count · score 0.22
type 2 diabetes mellitus · score 0.21
neutrophil percentage of leukocytes · score 0.19
intelligence · score 0.18
high density lipoprotein cholesterol measurement · score 0.18
schizophrenia · score 0.17
mathematical ability · score 0.17
heel bone mineral density · score 0.15
allergic rhinitis · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14519-F1	alphafold	PREDICTED	75.27	—

Amino-acid sequence (115 residues)

MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT QGTGNSQVPQ SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG LVRECLAETE RNARS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1)