Aquaporin-7 (AQP7)

About Aquaporin-7

Aquaporin-7 (AQP7) is a protein from Homo sapiens identified by UniProt accession O14520, 342 residues long. MolForge cross-references it against 0 known binders and 219 disease associations.

Target properties

Protein name	Aquaporin-7
UniProt accession	O14520
Gene	AQP7
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (219)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.22
nephrotic syndrome · score 0.08
familial idiopathic steroid-resistant nephrotic syndrome · score 0.08
focal segmental glomerulosclerosis · score 0.08
pentosuria · score 0.07
nephronophthisis · score 0.07
Balkan nephropathy · score 0.06
uridine-cytidineuria · score 0.06
isolated sedoheptulokinase deficiency · score 0.06
male infertility with teratozoospermia due to single gene mutation · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14520-F1	alphafold	PREDICTED	84.73	—

Amino-acid sequence (342 residues)

MVQASGHRRS TRGSKMVSWS VIAKIQEILQ RKMVREFLAE FMSTYVMMVF GLGSVAHMVL NKKYGSYLGV NLGFGFGVTM GVHVAGRISG AHMNAAVTFA NCALGRVPWR KFPVYVLGQF LGSFLAAATI YSLFYTAILH FSGGQLMVTG PVATAGIFAT YLPDHMTLWR GFLNEAWLTG MLQLCLFAIT DQENNPALPG TEALVIGILV VIIGVSLGMN TGYAINPSRD LPPRIFTFIA GWGKQVFSNG ENWWWVPVVA PLLGAYLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV LPKMGSHEPT ISPLTPVSVS PANRSSVHPA PPLHESMALE HF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards