About Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (SDHD) is a protein
from Homo sapiens identified by UniProt accession
O14521, 159 residues long.
MolForge cross-references it against 0 known binders and
232 disease associations.
Target properties
| Protein name | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial |
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| UniProt accession | O14521 |
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| Gene | SDHD |
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| Organism | Homo sapiens |
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| Length | 159 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (232)
Diseases linked to this target (Open Targets).
- paragangliomas 1 · score 0.83
- paragangliomas with sensorineural hearing loss · score 0.76
- Carney-Stratakis syndrome · score 0.76
- adrenal gland pheochromocytoma · score 0.75
- mitochondrial complex 2 deficiency, nuclear type 3 · score 0.70
- hereditary pheochromocytoma-paraganglioma · score 0.69
- mitochondrial complex II deficiency, nuclear type 1 · score 0.69
- Cowden syndrome 3 · score 0.68
- hereditary neoplastic syndrome · score 0.57
- Inherited cancer-predisposing syndrome · score 0.57
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O14521-F1 | alphafold | PREDICTED | 81.70 | — |
Amino-acid sequence (159 residues)
MAVLWRLSAV CGALGGRALL LRTPVVRPAH ISAFLQDRPI PEWCGVQHIH LSPSHHSGSK AASLHWTSER VVSVLLLGLL PAAYLNPCSA MDYSLAAALT LHGHWGLGQV VTDYVHGDAL QKAAKAGLLA LSALTFAGLC YFNYHDVGIC KAVAMLWKL
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