Nuclear envelope integral membrane protein 1 (NEMP1)

About Nuclear envelope integral membrane protein 1

Nuclear envelope integral membrane protein 1 (NEMP1) is a protein from Homo sapiens identified by UniProt accession O14524, 444 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Nuclear envelope integral membrane protein 1
UniProt accession	O14524
Gene	NEMP1
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.32
eosinophil percentage of leukocytes · score 0.25
apolipoprotein A 1 measurement · score 0.19
Red cell distribution width · score 0.16
allergic disease · score 0.15
asthma · score 0.15
insomnia · score 0.14
allergic sensitization measurement · score 0.13
Antihistamine use measurement · score 0.13
endometriosis · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O14524-F1	alphafold	PREDICTED	75.53	—

Amino-acid sequence (444 residues)

MAGGMKVAVS PAVGPGPWGS GVGGGGTVRL LLILSGCLVY GTAETDVNVV MLQESQVCEK RASQQFCYTN VLIPKWHDIW TRIQIRVNSS RLVRVTQVEN EEKLKELEQF SIWNFFSSFL KEKLNDTYVN VGLYSTKTCL KVEIIEKDTK YSVIVIRRFD PKLFLVFLLG LMLFFCGDLL SRSQIFYYST GMTVGIVASL LIIIFILSKF MPKKSPIYVI LVGGWSFSLY LIQLVFKNLQ EIWRCYWQYL LSYVLTVGFM SFAVCYKYGP LENERSINLL TWTLQLMGLC FMYSGIQIPH IALAIIIIAL CTKNLEHPIQ WLYITCRKVC KGAEKPVPPR LLTEEEYRIQ GEVETRKALE ELREFCNSPD CSAWKTVSRI QSPKRFADFV EGSSHLTPNE VSVHEQEYGL GSIIAQDEIY EEASSEEEDS YSRCPAITQN NFLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards